Drugs were scored according to their anticholinergic activity using the Anticholinergic Cognitive Burden (ACB) scale. It is already known that they can cause short-term confusion and raise people's risk of a fall. In addition, "many studies have linked anticholinergic drug use with concurrent or short term cognitive effects, but few have examined associations of long term anticholinergic exposure; the latter tend to report positive associations".
The researchers warn that the increasing tendency for older people to be taking a cocktail of drugs for different conditions may be part of the problem. Nevertheless, the team claims, the findings are signficant enough to warrant reduced prescribing anticholinergics, where possible "With many medicines having some anticholinergic activity, one key focus should be de-prescribing", states study co-researcher Ian Maidment, Ph.D., senior lecturer in clinical pharmacy at Aston University in the United Kingdom.
"The focus should be on de-prescribing at least some medicines. In the meantime, I strongly advise patients with any concerns to continue taking their medicines until they have consulted their doctor or pharmacist".
Anticholinergic drugs function by blocking the effects of acetylcholine, a chemical released by nerve cells to send signals to other nerves and muscles.
Previous literature has linked anticholinergic use to dementia, however these studies have been limited by their inability to determine if the increased risk is specific to the drug or the underlying conditions for which they were prescribed.
It analyzed data from the medical record of 40,770 patients between the ages of 65 - 99 that had been diagnosed with dementia between a period of April 2006 - July 2015.
"Having untreated depression is also a risk as people can die from that, so it is a question of balancing risks", he added. It could be that these medications are being prescribed for very early symptoms indicating the onset of dementia.
Anticholinergic antidepressants have been found to be linked with dementia, even when taken up to 20 years before a diagnosis.
The researchers do stress that patients prescribed anticholinergic drugs shouldn't just stop taking their medicines. "Not taking prescribed drugs could have serious consequences". The study's findings were published this week in BMJ.
But those individuals taking other classes of anticholinergics - including those used for asthma and gastrointestinal issues - were not at an increased risk of developing dementia compared with matched controls, the study found.
The research, funded by Alzheimer's Society, does not prove that some anticholinergics cause dementia but the authors said doctors should consider the long-term effects when prescribing.
"Doctors and patients should therefore be vigilant about using anticholinergic medications".
"But the headline claim that some drugs, especially antidepressants, can cause dementia up to 20 years later should be looked at closely".
He then answered "yes" when asked if he understood a court order not to have any contact with the victims or their families. Toronto's police chief, Mark Saunders , said nothing was being ruled out, and Minassian was not previously known to police.
It included Iran, Yemen, Somalia, Libya, and Syria and added Chad , another predominantly Muslim country. Trump issued, days after taking office, banning entry to the USA from several Muslim-majority countries.
The Mossad is believed to have assassinated Palestinian militants and scientists in the past, but rarely confirms such operations. Batsh was a lecturer at Universiti Kuala Lumpur , specializing in power engineering, according to the university.
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Amnesty International have described the actions against the Rohingya Muslims in the northern state of Rahkine as genocide. More than 70 people were killed in Burma in August past year after attacks on the police and military bases.
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Penguins forward Carter Rowney cross-checked Travis Konecny and roughed him up on the ice while the officials just watched. The Flyers could look to Nolan Patrick, the No. 2 overall pick of the 2017 draft, to play a more pivotal role next season.
Rusal was sanctioned this month by the Treasury's Office of Foreign Assets Control because of Deripaska's stake in the company. Daniel Briesemann, an analyst at German lender Commerzbank, said the Treasury's announcement should calm things down.
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