The wounded included 10 Vietnamese tourists, as well as the Egyptian bus driver and the guide.
Security forces are investigating, the ministry said.
This is Egypt's first attack against tourists using explosives since late 2015, when a bomb blew a Russian airliner out of the skies above the Sinai peninsula, killing all 224 people aboard.
Prime Minister Mostafa Madbouly, who visited the injured at Al-Haram hospital, said the bus had not followed the path it was supposed to take, where it would have been secured by police.
There were no immediate reports of any group saying it was behind the attack, but Islamist militants have targeted tourists in the past.
An explosion on Friday targeting a bus carrying Vietnamese tourists on an excursion to the Giza pyramids left four people dead and 10 others wounded, Egyptian authorities said.
The bus was traveling in the Marioutiyah area near the pyramids on Friday (local time) when the crude roadside bomb, concealed by a wall, went off.
"We have to know that it's possible that it would be repeated in the future".
In July 2017, two German tourists were stabbed to death by a suspected jihadist assailant at the Egyptian Red Sea beach resort of Hurgada.
"We have been in contact with the embassy of Vietnam to contain the impact of the incident, and what is important now is to take care of the injured", he said. Tourism is a huge sector of the Egyptian economy but has suffered since the Arab Spring in 2010.
The previous instance saw seven-year-old Jakelin Caal , also from Guatemala, die just hours after being taken into custody . Felipe Gomez Alonzo died Monday at a New Mexico hospital after suffering coughing, vomiting and fever , authorities said .
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Officials in North Dakota issued a no-travel advisory for the eastern part of the state due to icy roads and reduced visibility. A snow band is forming in southeastern North Dakota and into western Minnesota and is expected to continue southeastward.
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Italy's Mount Etna spews the ash and smoke in Sicily, Italy Monday in this still image from a video obtained by Reuters TV. Some buildings were reportedly damaged in what was the latest in dozens of tremors since Etna erupted on Monday.
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Gustafsson now headlines the new UFC 232 card from Los Angeles with tickets to The Forum going on sale this Wednesday, Dec. 26. Jones (22-1) is scheduled to meet Alexander Gustafsson (18-4) for the light heavyweight title.
Obviously, the first and second seed you would like, but I don't think we can get that now. James Conner will miss the Pittsburgh Steelers' game in New Orleans with an ankle sprain.
The Accidental Prime Minister trailer talk
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Trump to boy: Do you believe in Santa?
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Game Preview: Seattle Seahawks vs. Kansas City Chiefs
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