On Thursday, Shares of The Medicines Company (NASDAQ:MDCO), subtract -8.26% and closed at $35.33 in the last trading session. The last trading range of the stock ranges between $32.31 and $35.75. The Medicines Company (MDCO) recently offered a progress update on the ongoing ORION-1 study of PCSK9si, its investigational first-in-class PCSK9 synthesis inhibitor.
ORION-1 is a placebo-controlled, double-blind, randomized Phase II trial of single or multiple subcutaneous injections of PCSK9si in patients with atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (e.g., diabetes and familial hypercholesterolemia) and elevated LDL-C despite maximum tolerated doses of LDL-C lowering therapies. The study compares the effect of different doses of PCSK9si and evaluates the potential for a quarterly or bi-annual dosing regimen. The primary endpoint of the study is the percentage change in LDL-C from baseline at Day 180. The study exceeded its enrollment target of 480 patients ahead of plan, enrolling a total of 501 patients between January 21, 2016 and June 2, 2016.
An interim analysis of Day 90 follow-up for all 501 patients will be conducted and presented in the Late-Breaking Clinical Trial Session at the AHA Scientific Sessions 2016 on November 15, 2016 in New Orleans. In addition, the Company anticipates that top-line data from Day 180 follow-up for up to 200 patients will be presented at the Late-Breaking Clinical Trial Session and Day 180 follow-up in all 501 patients will be accomplished, analyzed and top-line results revealed before the end of 2016.
Cypress Semiconductor Corporation (NASDAQ:CY), remained flat and closed at $11.73 in the last trading session. The last trading range of the stock ranges between $11.60 and $11.80. The company’s Market capitalization is $3.72 Billion with the total Outstanding Shares of 321.18 million. Cypress Semiconductor Corp. (CY) recently declared that the programmability and SuperSpeed USB performance of its EZ-USB® FX3™ controller assisted startup SUB2r develop its unique, open-architecture camera platform. The SUB2r Alpha camera leverages the FX3 controller for USB 3.1 generation 1 bandwidth up to 5 Gbps, enabling it to stream uncompressed, high-definition (HD) video at both 4K at 30 frames per second (fps) and 1080p at 60 fps. FX3 allows audio captured by the camera’s onboard dual microphones or external microphones to be interlaced audio with the video stream. The controller also provides access to the camera’s output via USB or Gigabit Ethernet.
EZ-USB FX3 is the industry’s only programmable SuperSpeed USB peripheral controller. It is equipped with a highly configurable General Programmable Interface (GPIF™ II), which can be programmed in 8-, 16-, and 32-bit configurations. GPIF II allows FX3 to communicate directly with application processors, FPGAs, and image sensors and provides a data transfer rate at up to 400 Megabytes per second. FX3 manages the Alpha camera’s I2C configuration master for reconfiguration of the system’s FPGA over USB with remote updates. The solution adds to the flexibility of SUB2r’s camera platform, allowing users to optimize it for high quality streaming of virtual reality or video game play, motion pictures, 3D imaging, scientific research and many other applications.
American Electric Power Company Inc (NYSE:AEP), gained 0.11% and closed at $62.25 in the last trading session. The last trading range of the stock ranges between $61.72 and $62.51. During the 52-week trading session the minimum price at which share price traded, registered at $53.30 and reached to max level of $71.32. American Electric Power (AEP) is seeking offers for the supply of coal to one or more of its generating stations.
AEP is seeking spot delivery proposals for up to 300,000 tons of coal, FOB barge, starting in October 2016 and ending in December 2016. In addition, AEP is seeking spot delivery proposals for up to one million tons of coal, FOB barge, and up to 500,000 tons of coal, FOB CSX rail, in 2017. AEP is open to alternative pricing structures or other innovative, value-added concepts. Proposals with alternative terms will be accepted. Accepted bids will be at AEP’s discretion.