On Wednesday, Shares of Mallinckrodt PLC (NYSE:MNK), subtract -12.02% and closed at $59.65 in the last trading session. The last trading range of the stock ranges between $59.59 and $67.24. — Mallinckrodt plc (MNK), a leading global specialty pharmaceutical company, recently declared results of a post-hoc analysis of terlipressin clinical trial data presented at The Liver Meeting®1 — the 67th Annual Meeting of the American Association for the Study of Liver Diseases, held Nov. 11–15, 2016 in Boston, Mass. Terlipressin is being investigated for the treatment of HRS-1, an acute, rare and life-threatening condition requiring hospitalization, with presently no approved therapy in the U.S. or Canada. Terlipressin is approved for use in countries outside the U.S., counting several in Europe.
The Mallinckrodt-sponsored analysis, titled “Time for a New, More Inclusive Endpoint for Treatment of HRS-1? Small Changes in SCr of >20% Are Equivalent to HRS Reversal in Predicting Survival and Need for Renal Replacement Therapy During Treatment of HRS-1 With Terlipressin and Albumin,” analyzed findings from the leading prospective data set from two formerly accomplished [and published] studies evaluating terlipressin used in patients with HRS-1.6,7 Data were available for 308 patients with well-characterized HRS-1 from the two studies.
“Patients diagnosed with HRS-1 typically have a very poor prognosis, and there is a noteworthyunmet need for an approved treatment,” said Steven Romano, M.D., Chief Scientific Officer and Executive Vice President, Mallinckrodt. “This analysis underscores the clinical relevance of improvement in renal function in HRS-1 patients and supports our ongoing CONFIRM clinical trial,8 which is evaluating terlipressin as a potentially important therapy for U.S. patients.”
PPL Corp (NYSE:PPL), dropped -1.11% and closed at $32.87 in the last trading session. The last trading range of the stock ranges between $32.67 and $33.43. The company’s Market capitalization is $22.60 Billion with the total Outstanding Shares of 679.63 million. Southern Company, together with Louisville Gas and Electric Company and Kentucky Utilities Company (LG&E and KU), PPL Electric Utilities and the Tennessee Valley Authority (TVA), recently declared a new program designed to enhance the resiliency and reliability of the power grid by providing additional sources for obtaining critical equipment following disastrous events. The program – known as RESTORE, or Regional Equipment Sharing for Transmission Outage Restoration – will establish a voluntary program where participants identify spare transformers and other transmission equipment that would be made available for purchase by other participants should they experience a widespread disaster or physical attack within their service area.
“Utility partnerships are critical to successful recovery following disaster situations,” Southern Company Chief Transmission Officer Billy Ball said. “Southern Company has a history of assisting our neighbors in times of need, and the RESTORE program will continue that legacy while preparing for the threats facing the grid recently. This joint effort is intended to not only strengthen overall grid resiliency, but also benefit the customers we serve by adding flexibility to our recovery plans.”