On Friday, Shares of Dynavax Technologies Corporation (NASDAQ:DVAX), added 0.46% and closed at $10.82 in the last trading session. The last trading range of the stock ranges between $10.55 and $11.29. The company’s Market capitalization is $418.47 Billion with the total Outstanding Shares of 38.50 Billion. During the 52-week trading session the minimum price at which share price traded, registered at $10.11 and reached to max level of $29.86. Dynavax Technologies Corporation (DVAX) declared the first presentation of findings from an ongoing Phase 1/2 study evaluating SD-101, Dynavax’s intratumoral TLR9 agonist, in combination with Keytruda ® (pembrolizumab), Merck’s anti-PD-1 treatment. Early results evaluating five patients with metastatic melanoma for efficacy and 16 patients for safety were stated. In patients naïve to anti-PD-1 treatment objective responses were observed in three out of four (75%) counting one complete response (CR) and two partial responses (PR’s). One patient with progressive disease while receiving anti-PD-1 therapy was observed to have stable disease (SD). These data were presented in a poster session on Sunday at the European Society of Medical Oncology (ESMO) Annual Congress 2016 in Copenhagen, Denmark.
SD-101 in combination with pembrolizumab was well-tolerated. No dose-limiting toxicities of the combination were observed in any dose cohort, and a maximum tolerated dose (MTD) was not identified. No immune-related adverse events were stated, and the most common treatment-emergent adverse events were grade 1-2 flu-like symptoms, counting fever, chills and myalgia consistent with the engagement of TLR9 and production of interferon alpha. The study also included biomarker assessments suggesting that treatment with SD-101 and pembrolizumab resulted in elevation of gene signatures consistent with a boost in immune cell types and multiple immune functions.
Shares of United Parcel Service, Inc. (NYSE:UPS), subtract -0.28% and closed at $108.80 in the last trading session. The last trading range of the stock ranges between $108.48 and $109.36. The company’s Market capitalization is $95.25 Billion with the total Outstanding Shares of 690.00 Million. During the 52-week trading session the minimum price at which share price traded, registered at $87.30 and reached to max level of $111.83. During October, nearly 20,000 UPS® (UPS) employees on five continents around the world will take part in the company’s 14th annual Global Volunteer Month. Employees are expected to donate 325,000 volunteer hours to more than 300 community service events taking place across North America, Europe, Latin America, Asia Pacific and Indian subcontinent, Middle East and Africa (ISMEA).
“Volunteerism and diversity are at the heart of our culture,” said Eduardo Martinez, president of The UPS Foundation and chief diversity and inclusion officer of UPS. “UPS and The UPS Foundation are committed to community service all year round; by designating a specific month for an raised focus on volunteerism, we can take our commitment to the next level to make a noteworthydifference in our global communities.”
The theme for this year’s efforts is to volunteer and support non-profits and NGOs which focus on the development of women and young girls. This theme acknowledges UPS’s ten year anniversary of its Women’s Leadership Development program which is now a global network of UPS leaders dedicated to working together and across UPS to advance the aims of their community, careers and UPS.