On Friday, Shares of Exelixis, Inc. (NASDAQ:EXEL), subtract -1.75% and closed at $12.95 in the last trading session. The last trading range of the stock ranges between $12.33 and $13.34. The company’s Market capitalization is $2.93 Billion with the total Outstanding Shares of 230.33 million. During the 52-week trading session the minimum price at which share price traded, registered at $3.55 and reached to max level of $15.58. Exelixis, Inc. (EXEL) recently declared detailed results from the CABOSUN randomized phase 2 trial of cabozantinib in patients with formerly untreated advanced renal cell carcinoma (RCC) with intermediate- or poor-risk disease per the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC). Principal investigator Toni K. Choueiri, M.D. will present detailed data from late-breaking CABOSUN abstract [#LBA30_PR] recently in the Presidential Symposium 3 session, starting at 16:30 CEST (local Copenhagen time) / 10:30 a.m. EDT / 7:30 a.m. PDT at the European Society for Medical Oncology (ESMO) 2016, which is being held October 7 – 11, 2016 in Copenhagen.
CABOSUN was conducted by The Alliance for Clinical Trials in Oncology as part of Exelixis’ partnershipwith the National Cancer Institute’s Cancer Therapy Evaluation Program (NCI-CTEP).
In CABOSUN, with a median follow-up of 20.8 months, cabozantinib demonstrated a clinically meaningful and statistically noteworthy31 percent reduction in the rate of disease progression or death [HR 0.69, 95% CI (0.48-0.99), one-sided P=0.012]. The median progression-free survival (PFS) for cabozantinib was 8.2 months as compared to 5.6 months for sunitinib, corresponding to a 2.6 months (46 percent) improvement favoring cabozantinib over sunitinib. PFS benefits were independent of IMDC risk group (intermediate or poor risk) and presence or absence of bone metastases at baseline. The results for sunitinib were in line with a formerly published retrospective analysis of 1,174 intermediate- and poor-risk RCC patients from the IMDC database, which documented a median PFS of 5.6 months with a first-line targeted therapy, mainly sunitinib, in this patient population.1
Gold Fields Limited (ADR)(NYSE:GFI), dropped -0.35% and closed at $4.25 in the last trading session. The last trading range of the stock ranges between $4.16 and $4.40. The company’s Market capitalization is $3.48 Billion with the total Outstanding Shares of 821.53 million. During the 52-week trading session the minimum price at which share price traded, registered at $2.04 and reached to max level of $6.60. Gold Fields Limited produces gold and holds gold reserves in South Africa, Ghana, Australia, and Peru. It engages in underground and surface gold and surface copper mining and related activities, counting exploration, extraction, processing, and smelting. The company holds interests in eight operating mines with an annual gold production of about 2.16 million ounces, in addition to mineral reserves of about 46 million ounces and mineral resources of about 102 million ounces. It also produces copper in Peru and holds attributable copper mineral reserves totaling 532 million pounds and mineral resources totaling 910 million pounds.
On the other hand share PPL Corp (NYSE:PPL), lost -0.77% and closed at $32.25 in the last trading session. The last trading range of the stock ranges between $32.08 and $33.24. The company’s Market capitalization is $21.70 Billion with the total Outstanding Shares of 678.09 million. During the 52-week trading session the minimum price at which share price traded, registered at $32.08 and reached to max level of $39.92. PPL Corporation, a utility company, delivers electricity and natural gas in the United States and the United Kingdom. It serves 322,000 natural gas and 403,000 electric customers in Louisville and adjacent areas in Kentucky; 543,000 customers in central, southeastern, and western Kentucky; and about 28,000 customers in 5 counties in southwestern Virginia, and fewer than 10 customers in Tennessee. The company also provides electric delivery services to about 1.4 million customers in Pennsylvania; and operates 4 electricity distribution networks in the United Kingdom, in addition to delivers natural gas to customers in Kentucky; generates electricity from power plants in Kentucky; and sells wholesale electricity to 11 municipalities in Kentucky. In addition, it provides finance for the operations of PPL and auxiliaries.